


SAMe 400™ by AOR™ – S-Adenosyl-L-Methionine for Mood, Emotional Well-Being & Joint Support | 30 or 60 Tablets
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Description
Support a balanced mood, emotional wellness, and healthy joints with clinically researched SAMe.
KEY BENEFITS
- Helps support a balanced mood and emotional well-being
- Helps relieve symptoms of osteoarthritis
- Supports healthy joint function and mobility
- Provides 400 mg of S-adenosyl-L-methionine (SAMe) per tablet
- Supports the body’s natural methylation processes
- Enteric-coated tablets for targeted delivery
- Clinically researched dosage
- Available in 30 or 60 tablets
WHO IT’S IDEAL FOR
SAMe 400™ by AOR™ is ideal for adults who:
- Want natural support for mood and emotional well-being
- Experience mild symptoms of osteoarthritis
- Want to support joint comfort and mobility
- Need support for healthy methylation
- Prefer a clinically researched SAMe supplement
WHAT IT IS
SAMe 400™ by AOR™ is a high-potency S-adenosyl-L-methionine (SAMe) supplement formulated to support mood balance, emotional well-being, and joint health. Each enteric-coated tablet delivers 400 mg of SAMe, a naturally occurring compound involved in numerous biochemical reactions throughout the body.
SAMe serves as an important methyl donor, supporting the body’s methylation cycle, which plays a role in neurological function, joint health, and overall cellular processes. Clinical research has shown that SAMe may help relieve symptoms associated with osteoarthritis while supporting a healthy mood.
FEATURES
- Provides 400 mg of S-adenosyl-L-methionine (SAMe) per tablet
- Enteric-coated tablets for enhanced stability
- Supports mood and emotional well-being
- Helps relieve symptoms of osteoarthritis
- Supports healthy methylation pathways
- Clinically researched dosage
- Convenient once- or multiple-tablet daily dosing
- Available in 30 or 60 tablets
- NPN 80006060
MEDICINAL INGREDIENT
Each tablet contains:
- S-Adenosyl-L-Methionine (SAMe) — 400 mg
Non-Medicinal Ingredients
Stearic acid, magnesium hydroxide, microcrystalline cellulose, calcium oxide, shellac, arginine, magnesium stearate, silica, talc, sodium alginate, and glycerol.
RECOMMENDED DOSE
Adults: Take 2–3 tablets daily on an empty stomach, or as directed by a qualified healthcare practitioner.
- Use for at least 2 weeks for mood support.
- Use for at least 4 weeks for osteoarthritis symptom relief.
PAIR WITH
For comprehensive wellness support, pair with:
- Magnesium Supplements
- Joint & Connective Tissue Support Supplements
- Omega-3 Supplements
- B-Complex Vitamins
- Stress Support Supplements
CAUTIONS
- Do not take at night, as this product may cause anxiety, restlessness, or insomnia.
- Consult a healthcare practitioner prior to use if you are pregnant or breastfeeding.
- Consult a healthcare practitioner before use if you have depression or are taking medications that affect serotonin levels (such as antidepressants).
- Keep out of reach of children.
- Use only as directed.
FAQ
What is SAMe used for?
SAMe is commonly used to help support a balanced mood, emotional well-being, and relieve symptoms associated with osteoarthritis.
How long does it take to work?
For mood support, beneficial effects may be noticed after approximately 2 weeks of consistent use. For osteoarthritis support, a minimum of 4 weeks is recommended.
Should I take SAMe with food?
No. SAMe is best taken on an empty stomach for optimal absorption.
Can I take it before bed?
It is generally recommended not to take SAMe at night, as it may cause restlessness or interfere with sleep.
Why are the tablets enteric-coated?
The enteric coating helps protect SAMe from stomach acid, improving stability and allowing the ingredient to reach the intestine for absorption.
SAMe 400™ by AOR™ is a clinically researched S-adenosyl-L-methionine (SAMe) supplement formulated to support balanced mood, emotional well-being, healthy methylation, and joint health, while helping relieve symptoms associated with osteoarthritis.

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