SAMe 200 mg by Bioclinic Naturals® – Mood & Osteoarthritis Support | 30 Delayed-Release Tablets

Advanced SAMe Support for Joint Health & Methylation

SAMe 200 mg by Bioclinic Naturals® provides a clinically studied form of S-Adenosyl-L-Methionine (SAMe), a naturally occurring compound involved in hundreds of essential biological reactions. This delayed-release formula helps support healthy methylation pathways and is commonly used to help relieve osteoarthritic pain while supporting overall cellular function.

KEY BENEFITS

• Helps relieve osteoarthritic pain
• Supports healthy methylation pathways
• Contributes to glutathione production and antioxidant activity
• Supports normal cellular metabolism and function
• Features a stable, clinically tested SAMe disulfate tosylate form
• Enteric-coated tablets help protect SAMe from stomach acid degradation
• Delayed-release delivery enhances intestinal absorption
• Flexible dosing options for individualized support

WHO IT’S IDEAL FOR

• Adults seeking natural osteoarthritis support
• Individuals looking to support healthy methylation processes
• Those interested in antioxidant and cellular health support
• Adults requiring high-quality SAMe supplementation
• Individuals seeking a stable, well-absorbed SAMe formula

WHAT IT IS & HOW IT WORKS

SAMe (S-Adenosyl-L-Methionine) is a naturally occurring compound found throughout the body and serves as a critical methyl donor involved in more than 100 biological reactions. It plays important roles in DNA methylation, neurotransmitter metabolism, glutathione production, cellular growth, and antioxidant defense.

Bioclinic Naturals utilizes premium Italian Isoactive® SAMe produced through a natural fermentation process. The enteric-coated tablet protects the ingredient from stomach acid degradation and helps improve intestinal absorption for enhanced effectiveness.

FEATURES

• Provides 200 mg SAMe per delayed-release tablet
• Uses premium Italian Isoactive® SAMe
• Naturally fermented source
• Enteric-coated for enhanced absorption
• Stable SAMe disulfate tosylate complex
• Flexible dosing for individualized use
• Gluten-free
• Dairy-free
• Non-GMO
• Free from artificial colours, sweeteners, and preservatives

INGREDIENTS

Medicinal Ingredient (Per Tablet)

• SAMe (S-Adenosyl-L-Methionine) – 200 mg
(From 400 mg SAMe Tosylate Disulfate)

Non-Medicinal Ingredients

Microcrystalline cellulose, mannitol, enteric coating (methacrylic acid copolymer, triethyl citrate, glyceryl palmito-stearate, silica, titanium dioxide, medium chain triglycerides, yellow iron oxide), glyceryl behenate, vegetable-grade magnesium stearate, silica, sodium starch glycolate.

RECOMMENDED DOSE

For Mood Balance

Adults: Take 1–4 tablets twice daily on an empty stomach, or as directed by a healthcare practitioner.

Consult a healthcare practitioner for use beyond 6 weeks.

For Osteoarthritic Pain

Adults: Take 2 tablets three times daily on an empty stomach, or as directed by a healthcare practitioner.

Do not exceed 6 tablets daily.

Consult a healthcare practitioner for use beyond 12 weeks.

For best results, use for at least 2 weeks before evaluating effectiveness.

PAIR WITH

• Activated B-complex vitamins
• Vitamin B12 supplements
• Folate supplements
• Magnesium supplements
• Joint support formulas

FAQ

What is SAMe?

SAMe (S-Adenosyl-L-Methionine) is a naturally occurring compound involved in methylation, antioxidant production, neurotransmitter metabolism, and numerous cellular processes.

Why is this formula enteric-coated?

The delayed-release coating helps protect SAMe from stomach acid, allowing more of the active ingredient to reach the intestines for absorption.

How long does it take to work?

SAMe should generally be taken consistently for at least 2 weeks before effects are evaluated.

Why should SAMe be taken on an empty stomach?

Taking SAMe on an empty stomach helps maximize absorption and effectiveness.

What makes Isoactive® SAMe different?

Isoactive® SAMe is produced through a natural fermentation process and provides a highly stable, clinically tested form of SAMe.

CAUTIONS

Consult a healthcare practitioner before use if taking antidepressant medications. Do not use if pregnant or breastfeeding. Do not take at night, as SAMe may cause restlessness, anxiety, or insomnia. Individuals with bipolar disorder should not use SAMe unless under medical supervision. Possible side effects may include mild gastrointestinal upset, anxiety, insomnia, hyperactive muscle movement, or hypomania. Keep out of reach of children.

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SAMe 200 mg by Bioclinic Naturals is a delayed-release S-Adenosyl-L-Methionine supplement designed to help relieve osteoarthritic pain while supporting healthy methylation pathways, glutathione production, and cellular metabolism. Featuring premium Italian Isoactive® SAMe in a stable enteric-coated formulation, this clinically tested supplement helps improve absorption and provides flexible dosing for joint health, antioxidant support, and overall wellness.