Extra Strength Cold Daytime & Nighttime eZ Tabs by TYLENOL® – Multi-Symptom Cold Relief | 20 Tablets

Get relief from multiple cold symptoms throughout the day and night with TYLENOL® Extra Strength Cold eZ Tabs, combining pain and fever relief, cough suppression and nasal decongestion, with additional nighttime relief for runny nose and sneezing.

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KEY BENEFITS

• Provides multi-symptom cold relief
• Helps relieve nasal congestion
• Temporarily suppresses dry cough
• Reduces fever
• Relieves headaches, body aches and minor pains associated with colds
• Daytime and nighttime formulations for symptom relief
• Nighttime formula helps relieve runny nose and sneezing
• Contains 500 mg of acetaminophen per tablet for pain and fever relief
• Contains dextromethorphan for cough suppression
• Contains phenylephrine for nasal decongestion
• Nighttime tablets contain chlorpheniramine, an antihistamine
• Convenient eZ Tabs format designed for easy swallowing
• Suitable for adults and adolescents aged 12 years and older

Important product information: The supplied product title specifies 20 tablets, but the manufacturer’s description refers to a 40-tablet package containing 24 daytime and 16 nighttime tablets. The exact package count and daytime/nighttime tablet quantities must be verified against the product being sold.

WHO IT’S IDEAL FOR

TYLENOL® Extra Strength Cold Daytime & Nighttime eZ Tabs may be suitable for:

• Adults experiencing multiple common cold symptoms
• Individuals seeking relief from cold-related headaches and body aches
• People experiencing fever associated with a cold
• Those looking for temporary relief from dry cough
• Individuals experiencing nasal congestion
• People who experience runny nose or sneezing at night
• Adults who prefer separate daytime and nighttime cold formulations
• Adolescents aged 12 years and older who can safely use the product according to its label

Important: This medication is not appropriate for everyone. Individuals with certain medical conditions or taking other medications should consult a healthcare professional before use.

WHAT IT IS / WHAT IT DOES

TYLENOL® Extra Strength Cold Daytime & Nighttime eZ Tabs is a combination cold medication designed to provide temporary relief from several common cold symptoms.

The product contains separate daytime and nighttime formulations.

Daytime Formula

The daytime tablets combine three medicinal ingredients:

Acetaminophen: Relieves pain and reduces fever.

Dextromethorphan Hydrobromide: Temporarily suppresses dry cough.

Phenylephrine Hydrochloride: Included as an oral nasal decongestant.

Nighttime Formula

The nighttime tablets contain the same three ingredients, plus:

Chlorpheniramine Maleate: An antihistamine that helps relieve runny nose and sneezing.

Chlorpheniramine may cause drowsiness, making the nighttime formulation unsuitable for activities requiring alertness.

Understanding Nasal Congestion Relief

Although phenylephrine is included as an oral decongestant, evidence has raised significant questions about the effectiveness of oral phenylephrine at recommended doses for relieving nasal congestion.

The presence of phenylephrine should not be interpreted as a guarantee of meaningful congestion relief.

FEATURES

• TYLENOL® Extra Strength Cold
• Daytime and nighttime formulations
• Multi-symptom cold medication
• Extra-strength acetaminophen
• Dry cough suppressant
• Oral nasal decongestant ingredient
• Nighttime antihistamine
• Pain and fever relief
• Runny nose and sneezing relief with nighttime tablets
• Convenient eZ Tabs format
• Yellow daytime tablets
• Blue nighttime tablets
• For ages 12 years and older

Package size: Listed as 20 tablets; manufacturer copy also references a 40-tablet pack. Confirm the actual SKU before publication.

MEDICINAL INGREDIENTS

Daytime Formula — Yellow Tablets

Each daytime tablet contains:

Medicinal Ingredient	Amount	Purpose
Acetaminophen	500 mg	Pain reliever and fever reducer
Dextromethorphan Hydrobromide	10 mg	Cough suppressant
Phenylephrine Hydrochloride	5 mg	Oral nasal decongestant

Nighttime Formula — Blue Tablets

Each nighttime tablet contains:

Medicinal Ingredient	Amount	Purpose
Acetaminophen	500 mg	Pain reliever and fever reducer
Dextromethorphan Hydrobromide	10 mg	Cough suppressant
Phenylephrine Hydrochloride	5 mg	Oral nasal decongestant
Chlorpheniramine Maleate	2 mg	Antihistamine for runny nose and sneezing

Important Ingredient Considerations

Both formulations contain acetaminophen.

Do not combine daytime and nighttime tablets with other acetaminophen-containing products unless specifically directed by a healthcare professional.

Taking too much acetaminophen can cause severe liver damage, even when symptoms of overdose are not immediately apparent.

NON-MEDICINAL INGREDIENTS

According to the supplied manufacturer information:

• Cellulose
• Corn starch
• D&C Yellow No. 10 Aluminum Lake
• FD&C Blue No. 1 Aluminum Lake
• FD&C Yellow No. 6 Aluminum Lake
• Hypromellose
• Iron oxide black
• Magnesium stearate
• Polydextrose
• Polyethylene glycol
• Propylene glycol
• Sodium starch glycolate
• Titanium dioxide
• Triacetin
• Wax

The non-medicinal ingredient list may vary by formulation or packaging.

Always refer to the current product packaging for the complete and most up-to-date ingredient information.

DAYTIME COLD SYMPTOM RELIEF

The daytime formulation is designed to provide temporary relief from common cold symptoms without the additional antihistamine found in the nighttime tablets.

Helps Relieve Cold-Related Pain

Acetaminophen helps relieve:

• Headaches
• Minor body aches
• General aches and pains associated with colds

Reduces Fever

Acetaminophen also helps reduce fever associated with common colds.

Temporarily Suppresses Dry Cough

Dextromethorphan acts on the cough reflex to help reduce coughing.

It is intended for temporary cough relief and should not be used for persistent or chronic cough without medical advice.

Contains an Oral Decongestant

Phenylephrine is included for nasal congestion.

However, clinical evidence does not reliably demonstrate that oral phenylephrine provides meaningful nasal decongestion at standard recommended doses.

NIGHTTIME COLD SYMPTOM RELIEF

The nighttime formulation includes the same ingredients as the daytime tablets, with the addition of chlorpheniramine maleate.

Additional Nighttime Benefits

Chlorpheniramine helps relieve:

• Runny nose
• Sneezing

It may also cause drowsiness.

Nighttime Safety

Because chlorpheniramine can impair alertness:

• Avoid driving.
• Avoid operating machinery.
• Avoid alcohol.
• Use caution with sedatives or tranquilizers.
• Do not engage in activities requiring full alertness.

The nighttime formulation may also cause excitability in some individuals.

HOW THE MEDICINAL INGREDIENTS WORK

Acetaminophen — 500 mg

Acetaminophen is an analgesic and antipyretic.

It helps reduce fever and temporarily relieve minor aches and pains.

Acetaminophen does not treat the underlying viral infection responsible for the common cold.

Dextromethorphan Hydrobromide — 10 mg

Dextromethorphan is a cough suppressant.

It acts on the central nervous system to reduce the urge to cough.

It is generally used for temporary relief of dry cough.

Phenylephrine Hydrochloride — 5 mg

Phenylephrine is an alpha-adrenergic agonist included in oral cold medications as a nasal decongestant.

Although it is intended to reduce nasal congestion, evidence indicates that oral phenylephrine at recommended doses is not reliably effective for this purpose.

Phenylephrine may still cause adverse effects or interact with certain medications.

Chlorpheniramine Maleate — 2 mg (Nighttime Only)

Chlorpheniramine is a first-generation antihistamine.

It helps reduce symptoms such as runny nose and sneezing.

Because it can enter the central nervous system, it may cause:

• Drowsiness
• Reduced alertness
• Dry mouth
• Dizziness

Some individuals may experience excitability instead of sedation.

RECOMMENDED DOSE

Adults and Adolescents Aged 12 Years and Older

Take 1–2 tablets every 4 hours as needed.

Maximum Daily Dose

Do not exceed a combined total of 8 daytime and nighttime tablets within 24 hours.

This maximum applies to both formulations together.

For example:

Daytime Tablets	Nighttime Tablets	Total
4	4	8
6	2	8
2	6	8
8	0	8

Do not exceed the combined daily limit.

Important Dosing Instructions

• Use the smallest effective dose.
• Do not take more than recommended.
• Allow at least 4 hours between doses.
• Do not combine with other medications containing acetaminophen.
• Do not combine with other cough, cold or pain/fever medications unless approved by a healthcare professional.
• Follow the current product label.

Acetaminophen Content at the Maximum Dose

Eight tablets contain a total of 4,000 mg of acetaminophen.

This is the maximum daily acetaminophen amount commonly cited for adults, and lower limits may be appropriate for certain individuals.

Do not take additional acetaminophen from any other product.

FAQ

What is TYLENOL® Extra Strength Cold Daytime & Nighttime?

It is a combination cold medication containing separate daytime and nighttime tablets for temporary relief of multiple cold symptoms.

What symptoms does it relieve?

The formulations are intended to relieve:

• Cold-related aches and pains
• Fever
• Dry cough
• Nasal congestion

The nighttime formulation also helps relieve runny nose and sneezing.

What is the difference between the daytime and nighttime tablets?

Both contain acetaminophen, dextromethorphan and phenylephrine.

The nighttime tablets additionally contain chlorpheniramine, an antihistamine that helps relieve runny nose and sneezing and may cause drowsiness.

Does TYLENOL® Extra Strength Cold contain acetaminophen?

Yes.

Each daytime and nighttime tablet contains 500 mg of acetaminophen.

Does it help reduce fever?

Yes. Acetaminophen helps reduce fever.

Does it help with headaches and body aches?

Yes. Acetaminophen provides temporary relief from minor aches and pains associated with colds.

Does it help suppress dry cough?

Yes. Both formulations contain dextromethorphan, a cough suppressant.

Does it relieve nasal congestion?

The product contains oral phenylephrine, which is marketed as a nasal decongestant.

However, evidence indicates that oral phenylephrine at recommended doses is not reliably effective for nasal congestion.

Does the nighttime formula help with runny nose?

Yes. Chlorpheniramine helps relieve runny nose and sneezing.

Will the nighttime tablets make me sleepy?

They may.

Chlorpheniramine can cause drowsiness and reduced alertness.

Can I take the daytime tablets at night?

Follow the current package directions.

The daytime tablets do not contain the additional antihistamine found in the nighttime formulation.

Can I take the nighttime tablets during the day?

The nighttime tablets may cause drowsiness and should not be taken before driving or performing activities requiring alertness.

How often can I take TYLENOL® Extra Strength Cold?

The supplied directions state 1–2 tablets every 4 hours as needed, without exceeding 8 tablets total in 24 hours.

Can I take daytime and nighttime tablets on the same day?

Yes, according to the supplied directions, provided the combined total does not exceed 8 tablets within 24 hours and the required spacing between doses is maintained.

Can I take regular TYLENOL® with this product?

Do not combine this medication with other acetaminophen-containing products unless directed by a healthcare professional.

Excess acetaminophen can cause serious liver damage.

Can children use this product?

The supplied directions specify use for individuals aged 12 years and older.

Do not use in children younger than 12 years unless specifically directed by a physician.

Can I take this product if I have high blood pressure?

Consult a healthcare professional before use.

Phenylephrine may be unsuitable for individuals with high blood pressure or certain cardiovascular conditions.

Can I take it if I have thyroid disease?

Consult a healthcare professional before use.

Can I use this medication during pregnancy?

Consult a healthcare professional before use if pregnant.

Can I use it while breastfeeding?

Consult a healthcare professional before use if breastfeeding.

Can I drink alcohol while taking this medication?

Avoid alcohol.

Alcohol may increase the risk of adverse effects, including liver injury associated with acetaminophen and sedation associated with nighttime chlorpheniramine.

Can I take this medication with antidepressants?

Certain antidepressants may interact with dextromethorphan.

Do not use with monoamine oxidase inhibitors (MAOIs) or within 14 days of stopping an MAOI.

Other antidepressants may also interact. Consult a pharmacist before combining medications.

What should I do if I accidentally take too many tablets?

Contact a poison control centre or seek emergency medical assistance immediately, even if you feel well.

Acetaminophen overdose can cause severe liver damage before noticeable symptoms develop.

How many tablets are included?

The supplied title lists 20 tablets, while the manufacturer description refers to 40 tablets containing 24 daytime and 16 nighttime tablets.

The actual package configuration must be confirmed before purchase or publication.

CAUTIONS / WARNINGS

ACETAMINOPHEN OVERDOSE WARNING

Taking more than the recommended dose may cause severe or potentially fatal liver damage.

• Do not exceed 8 tablets combined within 24 hours.
• Do not use with other acetaminophen-containing products.
• Use the smallest effective dose.
• Do not combine with other cough, cold or pain/fever medications unless directed by a healthcare professional.

DO NOT USE

• If allergic to any medicinal or non-medicinal ingredient.
• With monoamine oxidase inhibitors (MAOIs).
• Within 14 days after stopping an MAOI.
• With other products containing the same medicinal ingredients.
• With other cough, cold or pain/fever medications unless approved by a healthcare professional.

CONSULT A HEALTHCARE PRACTITIONER BEFORE USE IF YOU:

• Have serious liver disease
• Have serious kidney disease
• Have chronic alcoholism
• Have high blood pressure
• Have heart disease
• Have thyroid disease
• Have diabetes
• Have glaucoma
• Have chronic lung disease
• Have asthma
• Have an enlarged prostate
• Are elderly
• Are pregnant or breastfeeding
• Take prescription medications
• Take non-prescription medications
• Use natural health products
• Take tranquilizers or sedatives

NIGHTTIME DROWSINESS WARNING

Nighttime tablets may cause drowsiness or excitability.

• Avoid alcohol.
• Do not drive.
• Do not operate machinery.
• Avoid activities requiring alertness.
• Consult a doctor before use with tranquilizers or sedatives.

STOP USE AND CONSULT A DOCTOR IF:

• Fever lasts more than 3 days.
• Cold symptoms last more than 5 days.
• Symptoms worsen.
• Cough persists.
• Symptoms are accompanied by a high fever.
• Thick yellow or green phlegm develops.
• Wheezing, rash or itching occurs.

Do not use for persistent or chronic cough associated with smoking, asthma or emphysema unless directed by a doctor.

SERIOUS ALLERGIC REACTIONS

Discontinue use if signs of an allergic reaction occur.

Seek emergency medical attention for:

• Difficulty breathing
• Swelling of the face, lips or throat
• Severe skin reactions

DRUG INTERACTIONS

Dextromethorphan can interact with certain antidepressants and other medications that affect serotonin.

Seek medical advice before use if taking antidepressants or other medications that may interact with the ingredients.

OVERDOSE WARNING

In case of overdose, contact a doctor or poison control centre immediately, even if no symptoms are present.

Possible symptoms include:

• Increased sweating
• Nausea
• Vomiting
• Stomach pain
• Loss of appetite

Do not wait for symptoms to appear.

PACKAGE SAFETY

Do not use if:

• The carton is open.
• The printed bottle-neck band is broken.
• The inner foil seal is damaged.
• The blister packaging is broken.

Keep out of reach of children.

This package contains enough medication to seriously harm a child.

LEGAL DISCLAIMER

Actual product packaging and materials may contain more and different information than what is shown on our website. We recommend that you do not rely solely on the information presented and that you always read labels, warnings, and directions before using or consuming a product.

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Extra Strength Cold Daytime & Nighttime eZ Tabs by TYLENOL® is a multi-symptom cold medication for temporary relief of fever, headaches, body aches and dry cough, with an oral decongestant ingredient and additional nighttime antihistamine relief for runny nose and sneezing. Each tablet contains 500 mg acetaminophen, 10 mg dextromethorphan hydrobromide and 5 mg phenylephrine hydrochloride, while nighttime tablets also contain 2 mg chlorpheniramine maleate. Intended for adults and adolescents aged 12 years and older. Package quantity requires verification: the supplied title specifies 20 tablets, while the manufacturer description specifies 40 tablets.