Griffonia | Thorne® | 90 Capsules

5-Hydroxytryptophan

Enhances sleep and helps manage stress*

5-HTP increases serotonin levels to promote restful sleep, manage stress, and decrease sugar cravings.* It contains pyridoxal 5'-phosphate, the active form of vitamin B6 and the necessary cofactor for the conversion of 5-HTP to serotonin.

Griffonia is a natural source of 5-Hydroxytryptophan (5- HTP), the intermediate metabolite produced when the body initiates the process of converting the essential amino acid L-tryptophan to serotonin. Serotonin levels in the body are associated with the regulation of sleep, mood, aggression, appetite, temperature, and pain sensation. 

Features

• Increases serotonin levels for sleep enhancement, decreased sugar cravings, and better stress management
• Helps regulate mood
• Can be taken with meals without competing with other amino acids

Ingredients

Non-Medicinal Ingredients

L-Leucine, Cellulose and Silicon dioxide in a hydroxypropyl methylcellulose capsule.

The serotonin levels in the body are associated with the regulation of sleep, mood, and appetite. A balanced serotonin level has been shown to support restful sleep, good mood, and decreased sugar cravings.* There are several ways to support a healthy serotonin level. L-tryptophan and 5-Hydroxytryptophan (5-HTP) are both precursors to serotonin. However, supplementation with 5-HTP is preferable, because unlike L-tryptophan, 5-HTP cannot be shunted into other uses in the body, such as niacin or protein production. 5-HTP is well absorbed by the body and easily crosses the blood-brain barrier where it can increase the synthesis of serotonin in the central nervous system.* And 5-HTP can be taken with meals without reducing its effectiveness.*

5-Hydroxytryptophan (5-HTP) is the intermediate metabolite the body produces when it initiates the process of converting the essential amino acid L-tryptophan to serotonin. Therefore, supplementation with 5-HTP will bypass the conversion of L-tryptophan into 5-HTP by the enzyme tryptophan hydroxylase – which is the rate-limiting step in the synthesis of serotonin – and is a conversion that can be inhibited by a number of factors, including stress, insulin resistance, increasing age, and deficiencies of vitamin C, folate, and iron.* 5-HTP is well absorbed when taken orally, with about 70 percent going into the bloodstream.* Intestinal absorption of 5-HTP does not require the presence of a transport molecule, and its absorption is not affected by the presence of other amino acids; therefore, 5-HTP can be taken with meals without reducing its effectiveness. 5-HTP has been shown to have a beneficial impact on mood, sleep, carbohydrate cravings, and discomfort associated with fatigue.* Numerous studies of individuals with negative mood status have shown significant positive response with 50-300 mg of 5-HTP daily.*

To further facilitate serotonin production, Thorne's 5-HTP formula contains pyridoxal 5'-phosphate, the active form of vitamin B6 and the necessary cofactor for the conversion of 5-HTP to serotonin. 5-HTP is commercially produced by extraction from the seeds of the African plant, Griffonia simplicifolia.

Each lot is thoroughly tested for contaminants, including Peak X, and is Peak X free.

Recommended Dose

Adults: Take with food. To promote healthy mood balance – 1-2 capsules, 3 times daily, or as recommended by a health-care practitioner. To minimize the risk of gastrointestinal side effects, start dosing at one capsule 3 times per day and slowly increase to effective dose over a period of 2 weeks. For use as a sleep aid: Take 2-4 capsules once daily or as recommended by a health-care practitioner. Take 30-45 minutes before bedtime.

Risk Information

If you are pregnant or breastfeeding, consult a health professional prior to use. If symptoms persist or worsen, consult a health professional. Consult a health professional if sleeplessness persists continuously for more than 3 weeks (chronic insomnia). Consult a health professional prior to use if you are taking carbidopa or drugs/supplements with serotonergic activity. These may include, but are not limited to, L-tryptophan, S-adenosylmethionine (SAMe), St. John’s wort, antidepressants, pain killers, over the counter cough and cold medication containing dextromethorphan, anti-nausea medication and anti-migraine medication. Some people may experience diarrhea, nausea, vomiting and abdominal pain. Discontinue use and consult a health professional if you show signs of weakness, oral ulcers, or abdominal pain accompanied by severe muscle pain or if you experience skin changes. Do not use if you have scleroderma. Some people may experience drowsiness. Exercise caution if operating heavy machinery, driving a motor vehicle or are involved in activities requiring mental alertness.

Keep out of reach of children. Do not use if security seal inside the cap is broken. Store tightly sealed in a cool, dry place.

Legal Disclaimer

This product is manufactured in the United States and is intended for use as a dietary supplement. Please be aware that this product has not been evaluated or approved by Health Canada, and it does not possess a Natural Product Number (NPN).

Important Information:

1. Health Claims: Any health claims made by this product have not been evaluated by Health Canada. This product is not intended to diagnose, treat, cure, or prevent any disease.

2. Usage: Use this product as directed on the label. Do not exceed the recommended dosage.

3. Consultation: Consult with a healthcare professional before use, especially if you are pregnant, nursing, have a medical condition, or are taking any medications.

4. Safety: Keep out of reach of children. In case of accidental overdose, seek professional assistance or contact a poison control center immediately.

5. Import Regulations: It is the responsibility of the consumer to ensure that this product complies with all local regulations and import requirements before purchasing and consuming this product.

6. Storage: Store in a cool, dry place, away from direct sunlight and heat.

By purchasing and using this product, you acknowledge and accept the terms of this disclaimer.

For any questions or concerns regarding this product, please contact our customer service team.