HistoDAO™ | Xymogen® | 60 Capsules



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Patented Diamine Oxidase Supplement

Support Healthy Degradation of Food-Derived Histamine

DAO Enzyme Supplements

18,000 HDU Per Serving to Support Gut Health

HistoDAO™ is a patented enzyme formula containing diamine oxidase (DAO)—the main enzyme responsible for the degradation of ingested histamine. This enzyme has been clinically tested and found to break down food-derived histamine in the digestive tract. DAO is not absorbed and does not have systemic activity. HistDAO does not manage or address antibody-related or IgE-related food allergies.


  • Supports Healthy Degradation of Food-Derived Histamine*
  • Enhances the Presence of Diamine Oxidase in the Digestive Tract*


Diamine Oxidase (from porcine kidney protein concentrate). Other Ingredients: Microcrystalline cellulose, HPMC (capsule), sucrose, rice starch, shellac, ascorbic acid, polyvinylpolypyrrolidone, hydroxypropyl cellulose, hydrated magnesium silicate, acetylated corn starch, sodium carboxymethylcellulose, and glycerol.


Take one to two capsules no more than 15 minutes before the consumption of histamine-rich foods, or take them as directed by your healthcare professional. Individuals taking medication should discuss potential interactions with their healthcare professionals. Avoid if allergic to pork or any other ingredient. HistDAO is NOT EFFECTIVE for symptoms of immune-related food allergies, such as peanuts, shellfish, etc., or for gluten intolerance due to sensitivity. Do not use if the tamper seal is damaged.

Cautions & warnings

If you are pregnant or breastfeeding, consult a healthcare practitioner prior to use. If you have coronary heart disease, hypertension, bronchial asthma or are taking H1 blockers, consult a health care practitioner prior to use. Not suitable for vegetarians (animal source of the enzyme). 

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Actual product packaging and materials may contain more and different information than what is shown on our website. We recommend that you do not rely solely on the information presented and that you always read labels, warnings, and directions before using or consuming a product.

Statements regarding dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease or health condition.

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