Methylfolate Plus™ | Biotics Research® | 120 Tablets



Shipping calculated at checkout


Methylfolate Plus by Biotics Research is a highly absorbable, activated form of folate: (6S)-5-Methyltetrahydrofolic acid, glucosamine salt

Methylfolate Plus serves a fundamental biochemical role in the body. Deficiency of this nutrient causes widespread symptoms and disorders. Similarly, supplementation of this nutrient can be helpful in a host of chronic concerns.



  • ACTIVATED FORM OF FOLATE: Methylfolate Plus supplies folate in the active form. Folate deficiency is one of the common vitamin deficiencies. Methylfolate Plus does not require enzymatic conversion to 5-MTHF in the body, which benefits those who cannot convert folic acid due to a genetic defect, and the general population who is suspected to convert only a amount of folic acid.
  • SUPPORTS CARDIOVASCULAR HEALTH: Methylfolate Plus provides nutritional support that may help homocysteine levels in the normal range.
  •  PROMOTES HEALTHY NERVOUS SYSTEM: Combination formulas of and folate support neurological health throughout all stages of life. Folate may also reduce the risk of neural tube defects.
  • NPN: 80040077 


Methylfolate Plus™ supplies folate, in the active form of (6S)-5-Methyltetrahydrofolic acid, glucosamine salt. Methylfolate is a highly absorbable, activated form of folate, which does not require enzymatic conversion to 5-methylfolate in the body. The glucosamine salt form utilized in Methylfolate Plus™ is more stable than other forms of methylfolate often used. Folate deficiency is one of the most common vitamin deficiencies. In individuals with homozygous (TT) or heterozygous (CT) genetic predisposition, eating folate-rich foods may not provide the recommended daily dosage of folate; thus the need for supplementation. By providing 5-methylfolate directly, Methylfolate Plus™ and may have benefits for those who do not produce enough 5-methylfolate in response to folic acid supplementation. Each serving (½ tablet) of Methylfolate Plus™ supplies 400 mcg of folate as 5-methylfolate, combined with 25 mcg of vitamin B12 as methylcobalamin in our biologically active, phytochemically rich vegetable culture base.



To increase folate deficiency. Consider for Metals Detox.
5-methyltetrahydrofolic acid is a highly absorbable, activated form of folate, which does notrequire enzymatic conversion to 5-methylfolate in the body. The glucosamine salt formutilized in Methylfolate Plus™ is more stable than other forms of methylfolateoften used. 5-methyltetrahydrofolic acid studies indicate reduced homocysteine levels and improves vascular endothelial function. It plays a key role in the synthesis of nucleic acids (for DNA production and repair, aids in single carbon metabolism (methylation and glutathione production), interconversion of amino acids (for neurotransmitter production and detoxification), aids in the formation and maturation of RBC, WBC and platelet production, aids in ulcerative colitis and preventing cervical dysplasia. May help to treat vitiligo as well as neurological disorders. May help to improve cognitive function and restless leg syndrome, dementia, and insomnia. May help with depression and schizophrenia like syndromes and may help prevent neural tube defects in newborns when taken during pregnancy.



Each Tablet Contains:
folate as 5-methylfolate
400 mcg
B12 as methylcobolamin
25 mcg


Suggested dose

1/2 tablet daily as recommended by your health care practitioner.


About Biotics Research®

WHO WE ARE: Biotics Research was the first company to introduce a natural form of CoQ10 as a dietary supplement into the US market in 1979. We have revolutionized the nutritional supplement industry by utilizing “The Best of Science and Nature”. We drive advancement by focusing our initiatives on research, natural effectiveness, product safety, efficacy, unparalleled quality control and continuing innovation.

QUALITY MADE IN THE USA: We produce tablets, capsules, powders and liquids in our Rosenberg, Texas, Texas Department of Health licensed, GMP-certified production and laboratory facility. Our products are tested in our state-of-the-art laboratory to ensure their safety, efficacy, and purity, and Methylfolate Plus, like all Biotics Research products, is Gluten Free!

Legal Disclaimer

Estimate shipping

You may also like