5-HTP Time Release | Bioclinic® Naturals | 60 Time Release Caplets



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Healthy Mood Balance

5-HTP (5-Hydroxytryptophan)100 mg

60 Time Release Caplets 

5-HTP (5-hydroxytryptophan) is an amino acid precursor to the brain chemical serotonin, a neurotransmitter that is essential for balancing mood, along with performing cognitive tasks such as learning and memory formation. Lowered mood as well as other conditions have long been associated with low serotonin levels, making 5-HTP an attractive natural option to elevate mood and improve emotional health. Timed-release caplets bypass the limitations of immediate-release formulations. This allows for a sustained increase in serotonin, avoiding spikes, fluctuations, and the rapid drops associated with missed or delayed dosing. Additionally, timed-release formulations may help minimize the gastric discomfort some individuals experience with 5-HTP.


  • Extra-strength 100 mg formula for ease of dosing
  • Naturally sourced from the seed of the African plant Griffonia simplicifolia
  • 5-HTP readily crosses the blood-brain barrier to increase central nervous system synthesis of serotonin
  • Timed-release formulation may minimize gastric discomfort and helps prevent the rapid spikes and drops associated with immediate-release 5-HTP

Clinical research supports 5-HTP supplementation for mood. A randomized double-blind clinical trial of 60 patients assessed the efficacy of 5-HTP supplementation as compared to fluoxetine. Efficacy was determined by comparing initial HAM-D scores obtained at baseline to those at 2 weeks, 4 weeks, and 8 weeks. Following 5-HTP supplementation, 73% of patients taking 5-HTP and 80% of patients taking fluoxetine showed significant reduction in HAM-D scores starting at week two and through to the end of the study.

5-HTP has also been used to address serotonin imbalance implicated in chronic pain conditions including migraines as well in fibromyalgia and insomnia. People with fibromyalgia who take 300–400 mg of 5-HTP daily in divided doses have reported improvements in symptoms, including pain severity, morning stiffness, and sleeplessness. 5-HTP is known to increase sleep quality, which is critical in those suffering from fibromyalgia. In fact, 5-HTP has been shown to promote REM sleep in healthy adults. The increased time spent in REM sleep is one of the reasons why 5-HTP is considered a sleep aid. 

Medicinal Ingredients

Each Capsule Contains:
L-5-Hydroxytryptophan (Griffonia simplicifolia) (seed) 100 mg

Non-Medicinal Ingredients

Dicalcium phosphate, microcrystalline cellulose, carbohydrate gum, coating (carbohydrate gum, glycerin), vegetable grade magnesium stearate (lubricant).


Recommended Adult Dose: Healthy Mood Balance: 1 caplet 3 times per day with food or as directed by a health care practitioner. To minimize the risk of gastrointestinal side effects, start dosing at 100 mg 2–3 times per day and slowly increase to effective dose over a period of 2 weeks . Use for at least 1 week to see beneficial effects. Consult a health care practitioner for use beyond 1 year . Sleep Aid: 1 caplet 1–2 times per day with food or as directed by health care practitioner . Take 30–45 minutes before bedtime.


Contains no artificial colours, preservatives, or sweeteners; no dairy, starch, sugar, wheat, gluten, yeast, soy, corn, egg, fish, shellfish, animal products, salt, tree nuts, or GMOs. Suitable for vegetarians/vegans. Sealed for your protection. Do not use if seal is broken. For freshness, store in a cool, dry place. 


Do not use if you have scleroderma. 

Drug Interactions

Combining 5-HTP with serotonergic drugs such as antidepressants, dextromethorphan (in cough syrups), meperidine (Demerol), tramadol, and other drugs may increase the risk of serotonergic side effects such as serotonin syndrome.14 Combining 5-HTP and carbidopa-levodopa (Sinemet®) can increase the risk of serotonergic side effects. This combination might increase the risk of some side effects including hypomania, restlessness, rapid speech, anxiety, insomnia, and aggressiveness, as well as scleroderma-like skin reactions.15,16 Individuals using this drug combination should be monitored by a health care practitioner. 5-HTP lowers blood pressure and could be additive to antihypertensive drugs.17 Clinically, long term use of 5-HTP may need the use of dopamine amino acid precursors to support mood.18

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* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

The product information on this website may not be 100% accurate. Please ensure to check the product packaging information before consumption, especially if you have allergies or other health conditions.

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