Calcium D-Glucarate | Thorne | 90 Capsules

Women's Health

Inositol, CoQ10, Folate, and Polyphenols

Promote Healthy Ovarian Function and Reproductive Health

Calcium D-Glucarate (CDG) has been shown to promote liver detoxification by enhancing the metabolism of hormones and environmental toxins. It also helps maintain normal cholesterol levels.

Calcium D-Glucarate (CDG) is produced naturally in small amounts by humans. CDG supplementation has been shown to prevent the recycling of hormones and undesirable environmental toxins, thereby promoting liver detoxification and the excretion of these potentially detrimental substances.* Other applications of CDG supplementation include the maintenance of already normal cholesterol levels and facilitating healthy hormone metabolism.

Features

• Menstrual Balance: Supports balanced hormone levels and menstrual cycle regularity
• Ovarian Care: Provides nutritional support for women and enhances ovarian response and function
• Fertility Support: Supports natural fertility and promotes a healthy response to assisted reproduction efforts
• Effective Ingredients: Thorne’s Ovarian Care offers a unique blend of nutrients and botanical extracts, including Myo-inositol and D-chiro-inositol, Coenzyme Q10, folate, and polyphenols for women seeking support for menstrual regularity and various aspects of fertility health
• Trusted: Thorne is chosen by elite athletes and trusted by 100+ pro teams. Thorne is the only supplement manufacturer to collaborate with Mayo Clinic on wellness research and content. Thorne is also a proud partner of 12 U.S. Olympic Teams
• Dietary Supplement
• Liver/Detox
• Women's Health
• Gluten Free

How does it work?

Glucuronidation is the liver's normal process of attaching a glucuronic acid molecule to potentially harmful substances to detoxify and eliminate them from the body.* During phase II liver detoxification, certain hormones and various fat-soluble toxins will undergo glucuronidation and be excreted through the bile or urine. Calcium D-Glucarate helps this elimination process to occur uninterrupted.

The more detailed version: Upon ingestion and exposure to the acidic environment of the stomach, Calcium D-Glucarate is metabolized to form D-glucaric acid. D-glucaric acid is further metabolized in the gastrointestinal tract into three compounds that exist in equilibrium and are comprised of approximately 40-percent D-glucaric acid, 30-percent D-glucaro-1,4-lactone, and 30-percent D-glucaro-6,3-lactone. These compounds are then transported to the blood and various internal organs, and subsequently excreted in the urine and bile. Although D-glucaro-1,4-lactone is apparently the most pharmacologically active of the three, it is not commercially available. Also, Calcium D-Glucarate administration results in longer inhibition of beta-glucuronidase (five hours versus one hour) than does D-glucaro-1,4-lactone, so it is the compound used.

Calcium D-Glucarate's detoxifying and chemopreventive properties are attributable to its ability to increase glucuronidation, and the accompanying excretion of harmful compounds.* It does so by inhibiting the enzyme beta-glucuronidase.* During Phase II detoxification, hormones and various undesirable lipid-soluble toxins are bound to glucuronic acid in the liver (glucuronidation) and excreted through the biliary tract; however, beta-glucuronidase can unbind these toxins, which makes it possible for them to be reabsorbed rather than excreted. D-glucaro-1,4-lactone is the metabolite that most inhibits the activity of beta-glucuronidase, thereby increasing the excretion of toxic compounds and decreasing the activity of harmful substances that are most active in their unbound state.* Inhibition of beta-glucuronidase by Calcium D-Glucarate metabolites ultimately results in potentially decreasing the risk of toxicity.

In addition, by reducing the activity of beta-glucuronidase and the viability of harmful intestinal bacteria, the salts of D-glucaric acid have been shown to enhance enterohepatic circulation and reduce cholesterol synthesis, thus resulting in maintenance of healthy cholesterol levels.

Medicinal Ingredients

Non-Medicinal Ingredients

Hypromellose Capsule, Leucine

Recommended Dose

Take 1 capsule three times daily or as recommended by your health professional.

Cautions

ALLERGY WARNING

This product is contraindicated in an individual with a history of hypersensitivity to any of its ingredients.

PREGNANCY

If pregnant, consult your health professional before using this product.

INTERACTIONS

There are no known adverse interactions or contraindications at publication date.

Legal Disclaimer

Actual product packaging and materials may contain more and different information than what is shown on our website. We recommend that you do not rely solely on the information presented and that you always read labels, warnings, and directions before using or consuming a product.