SynovX Protect | Xymogen® | 120 Capsules

Medicinal Ingredients

Non-Medicinal Ingredients

Hypromellose capsule, ascorbyl palmitate, silica, medium chain triglycerides. 

CS BIO-ACTIVE Chondroitin sulfate (CS) is the most abundant glycosaminoglycan (GAG) in the body. CS is required for the formation of proteoglycans in joint cartilage. GAGs are the principal components of cartilage and synovial fluid; they bind with core proteins to form the proteoglycans that provide structure to and support the function of connective tissue. CS is thought to enhance joint health by supporting endogenous synthesis and preventing degradation of other joint GAGs. Oral administration of CS (800-1200 mg/d) has proven to positively influence joint space width, joint comfort, and fluid accumulation.- SynovX Protect provides 1,200 mg of CS in the recommended four-capsule-per-day dosage.

The pharmaceutical grade, low-molecular-weight CS in CS BIO-ACTIVE has demonstrated higher bioavailability!5) and greater biological activity than other CS sources. CS BIO-ACTIVE is the reference CS for the European Union Pharmacopoeia, and it was selected by the US National Institutes of Health for their glucosamine/chondroitin trial. In fact, most of the clinical research performed using CS has employed CS BIO-ACTIVE; and in all clinical trials and over 10 years of pharmacovigilance, CS BIO-ACTIVE has shown an excellent safety profile.

Glucosamine Sulfate Glucosamine is a naturally occurring amino saccharide (glucose with a nitrogen-containing amino group attached) that is a principle substrate for cartilage synthesis. Research suggests that glucosamine stimulates chondrocytes (cartilage cells), supports GAG synthesis, incorporates sulfur into cartilage tissue, induces hyaluronic acid (HA) production, and modulates prostaglandin (e.g., PGE2) synthesis.(9-111 Prostaglandins (specialized hormone-like fatty acids produced in the body) regulate a wide variety of bodily functions, including cytokine production and balance. Glucosamine sulfate was found to inhibit the release of PGE2, the activity of NF-kappaB, and the synthesis of COX-2 enzymes in human chondrocytes.

Most of the scientific research done on glucosamine has been performed using glucosamine sulfate. Oral doses of 1,500 mg/d have shown clinical benefits in joint mobility and comfort. Four capsules per day of SynovX Protect provide 1,500 mg of glucosamine sulfate. It is postulated that even lower doses may nourish joint tissues, especially in combination with chondroitin sulfate.

Several studies have confirmed that the benefits of combining glucosamine sulfate with chondroitin sulfate outweigh taking them alone.(14-16) During a randomized, double-blind, placebo-controlled clinical trial that followed 605 participants for two years, all study groups who had received glucosamine sulfate (1,500 mg/d), chondroitin sulfate (800 mg/d), or a combination of the two experienced an improvement in joint comfort. However, only the group that received a combination of glucosamine sulfate and chondroitin sulfate experienced a significant reduction in joint space width.

Methylsulfonylmethane (MSM) As an organosulfur compound, MSM is thought to primarily benefit joint tissues by delivering sulfur. Sulfur helps maintain the strength and structure of connective tissue by forming cross- linkages through disulfide bonds-such as those found in GAGs.(18) Research suggests that MSM may reduce joint tissue damage triggered by free radicals. One joint study shows that glucosamine and MSM achieve better results when combined than when administered individually.

MSM's effect on free radicals also appears to support muscle recovery after exercise. Studies suggest that the significant increase in total antioxidant capacity observed subsequent to MSM supplementation was the key factor responsible for reducing muscle soreness and breakdown, which can occur after rigorous exercise. Though relatively high levels of MSM were used in the studies-1.5-3 grams total per day in Kalman's study and 50 milligrams per kilogram per day in Barmaki's study -the one gram of MSM provided in two servings of SynovX Protect can contribute to MSM dosing for exercise recovery.

Directions

Adults: Take 4 capsules daily, or as directed by your healthcare professional. Use for a minimum of 1 month to see beneficial effects.

Caution

Consult your healthcare practitioner prior to use if you are pregnant or breastfeeding. Consult a healthcare practitioner if symptoms worsen. Stop use if diarrhoea, abdominal pain, heartburn, nausea or vomiting occur.